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. Author manuscript; available in PMC: 2017 Oct 26.
Published in final edited form as: Science. 2015 May 21;348(6237):aaa6566. doi: 10.1126/science.aaa6566

Figure 2. Activation and functions of ILCs.

Figure 2

The tissue signals that expand and activate ILC1s, ILC2s and ILC3s, and the effector functions of ILCs, mirror the activation and functions of T cells. In this figure, NK cells, ILC1s, ILC2s and ILC3s could be replaced by CD8+ T cells, Th1, Th2 and Th17 cells, respectively. However, while ILCs are activated promptly by tissue signals and therefore act upstream in the immune response, T cells are first selected and expanded on the basis of T cell receptor specificity, a process that typically requires several days.

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