Table 1  Amenorrhoea rates after chemotherapy in premenopausal patients with breast cancer, overview, taken from 13 .

Age (years)	Chemotherapy	Amenorrhoea rate (%)
A = doxorubicin; C = cyclophosphamide; E = epirubicin; F = 5-fluorouracil; M = methotrexate
> 40	6 × CMF, 6 × FEC, 6 × FAC	> 80 (high risk)
< 40	EC (dose dense)
30 – 39	6 × CMF, 6 × FEC, 6 × FAC	20 – 80 (moderate risk)
> 40	4 × AC
< 30	6 × CMF, 6 × FEC, 6 × FAC	< 20 (low risk)
< 40	4 × AC