Panel A: Subcutaneous injection of the NSAID flunixin increased the mechanical paw withdrawal thresholds of nerve-cuffed mice toward a pre-surgical level, T-test, t16 = 3.5, P < 0.01. Panel B: Nerve-cuffed mice were able to generate SIA when pre-treated with analgesic. Two-Way ANOVA, * - significant for interaction (pain × drug), F1,44 = 4.7, P < 0.05.