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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Am J Transplant. 2017 May 24;17(11):2841–2850. doi: 10.1111/ajt.14327

Figure 2. Correlation heat map demonstrating Spearman’s rank correlation coefficients comparing expression of 34 antibody-mediated rejection (AMR) related genes with Banff histology scores and DSA status.

Figure 2

Endothelial genes demonstrate the strongest correlation with lesions associated with antibody-mediated rejection (C4d, DSA, cg, g, ptc). Inflammation-related genes generally correlate with T-cell mediated rejection lesions (t, i, ti). Histologic lesions associated with chronic injury (cv, ci, ct) also correlate with endothelial genes. Abbreviations: AMR, antibody-mediated rejection; cg, transplant glomerulopathy; ci, interstitial fibrosis; ct, tubular atrophy; cv, arterial fibrous intimal thickening; DSA, donor specific antibody; g, glomerulitis; i, interstitial inflammation; mm, mesangial matrix increase; ptc, peritubular capillary margination; t, tubulitis; TCMR, T-cell mediated rejection; ti, total interstitial inflammation; v, intimal arteritis.