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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Am J Transplant. 2017 May 24;17(11):2841–2850. doi: 10.1111/ajt.14327

Figure 6. Principal component analysis demonstrating relationships between immunopathologic features, antibody-mediated rejection (AMR) 3-gene set expression, and Banff 2015 diagnostic categories.

Figure 6

Principal components (PC) 1 and 2 primarily separate the diagnostic categories along AMR and T-cell mediated rejection (TCMR) continuums, respectively. There is a general association between AMR-associated features (AMR 3-gene set, cg, C4d, DSA, g, mm) and AMR cases as well as between TCMR-associated features (t, i, ti) and TCMR cases. Intermediate between these two clusters are lesions of chronicity (cv, ci, ct) as well as ptc and v-lesions. Abbreviations: cg, transplant glomerulopathy; ci, interstitial fibrosis; ct, tubular atrophy; cv, arterial fibrous intimal thickening; DSA, donor specific antibody; g, glomerulitis; i, interstitial inflammation; mm, mesangial matrix increase; ptc, peritubular capillary margination; t, tubulitis; ti, total interstitial inflammation; v, intimal arteritis.