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. 2017 Oct 14;23(38):6962–6972. doi: 10.3748/wjg.v23.i38.6962

Figure 3.

Figure 3

The effects of a short course of rapamycin treatment on naïve and effector memory cells (A) seems to transiently inhibit the T cell function (B). A: The ndLNs, dLNs and spleens of grafted animals were collected on day 11 and day 42 and conventional T cells were analyzed by flow cytometry. Naïve T cells, defined as CD62L+CD45RC+, and effector/memory cells, defined as (CD62L-CD45RC-) + (CD62L+CD45RC-) + (CD62L-CD45RC+), were analyzed in CD4+Foxp3- and CD8+Foxp3- T cell populations. The results are expressed as the mean +/- SEM of the percentages of effector/memory and naïve T cells, respectively. P-values are indicated when the differences between the two groups of rats are significant (aP ≤ 0.05). The graph shows the cumulative data from 4-5 rats/group; B: Quantification of IFNγ and TNFα expression by CD4+ and CD8+ T cells in the dLNs of grafted animals after PMA/ionomycin stimulation for 4 h. The graph shows the cumulative data from 4-5 rats/group. The results are expressed as the mean +/- SEM. P-values are indicated when the differences between the two groups of rats are significant (aP ≤ 0.05).