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. 2017 Oct 14;23(38):6995–7008. doi: 10.3748/wjg.v23.i38.6995

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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Mfn2 knockdown relieves endoplasmic reticulum Ca²⁺ decrease. FLUOFORTE^® Calcium Assay and thapsigargin were used to detect ER Ca²⁺ concentrations by VarioskanFlash. Taking the hypoxia group as the reference, both the NC and hypoxia + Si groups showed higher ER Ca²⁺ concentrations. ER: Endoplasmic reticulum; Mfn2: Mitofusin-2; NC: Normal culture. ^cP < 0.001.