Table 1.
Demographic and preoperative data
| Variable | Total, n = 1000 | First 10 yr, 1993-2002 | Second 10 yr, 2003-2012 | Last 5 yr, 2013-2017 | P-value |
| Age in yr | 54 (12-88) | 53 | 55 | 55 | 0.22 |
| Sex | |||||
| Male | 614 (61.4) | 190 (63.3) | 260 (58.8) | 164 (63.6) | 0.33 |
| Female | 386 (38.6) | 110 (36.7) | 182 (41.2) | 94 (36.4) | |
| DM | 145 (14.5) | 39 (13) | 60 (13.6) | 46 (17.8) | 0.21 |
| BMI in kg/m2 | |||||
| < 25 | 723 (72.3) | 250 (38.3) | 326 (73.8) | 147 (57) | 0.0001 |
| > 25 | 277 (27.7) | 50 (16.7) | 116 (26.2) | 111 (43) | |
| Abdominal pain | 753 (75.3) | 230 (76.7) | 329 (74.4) | 194 (74.2) | 0.12 |
| Jaundice | 909 (90.9) | 265 (88.3) | 406 (91.9) | 238 (92.2 | 0.18 |
| Preoperative biliary drainage | 511 (51.1) | 163 (54.5) | 226 (51.1) | 122 (47.3) | 0.23 |
| Preoperative serum albumin in mg | 4 (3.2-5.2) | 4.1 | 4 | 3.9 | 0.23 |
| Preoperative serum bilirubin in mg | 4 (0.5-38) | 3.1 | 4.7 | 4.3 | 0.0001 |
| Preoperative CEA | 6.4 (0.5-394) | 8 | 8 | 6 | 0.09 |
| Preoperative CA19-9 | 27 (0.5-1200) | 32 | 33 | 34 | 0.12 |
Data are presented as n (%) or n (range), unless otherwise indicated. BMI: Body mass index; CEA: Carcinoembryonic antigen; DM: Diabetes mellitus.