Table 2.
ORs, 95% CIs, and P-values for each genetic model in the association of SNPs rs2075876 (G > A) and rs760426 (A > G) with RA risk (NA = not available; OR = odds ratio; CI = confidence interval; *literature data.
| polymorphism | study | Genetic model | OR | 95%CI | P | ||
|---|---|---|---|---|---|---|---|
| SNP rs2075876 ( G > A ) | Terao C, 2011 | A | Allelic* | (A vs. G) | 1.21 | 1.09–1.36 | <0.001 |
| Dominant | (AG + AA vs. GG) | 1.18 | 1.06–1.32 | 0.002 | |||
| Recessive | (AA vs. AG + GG) | 1.53 | 1.31–1.79 | <0.001 | |||
| Codominant heterozygous | (AG vs. GG) | 1.08 | 0.96–1.21 | 0.168 | |||
| Codominant homozygous | (AA vs. GG) | 1.60 | 1.35–1.89 | <0.001 | |||
| B | Allelic* | (A vs. G) | 1.18 | 1.07–1.30 | <0.001 | ||
| Dominant | (AG + AA vs. GG) | 1.31 | 1.19–1.45 | <0.001 | |||
| Recessive | (AA vs. AG + GG) | 1.09 | 0.95–1.26 | 0.204 | |||
| Codominant heterozygous | (AG vs. GG) | 1.32 | 1.20–1.47 | <0.001 | |||
| Codominant homozygous | (AA vs. GG) | 1.27 | 1.09–1.48 | 0.002 | |||
| C | Allelic* | (A vs. G) | 1.15 | 1.06–1.24 | <0.001 | ||
| Dominant | (AG + AA vs. GG) | 1.18 | 1.09–1.27 | <0.001 | |||
| Recessive | (AA vs. AG + GG) | 1.25 | 1.12–1.39 | <0.001 | |||
| Codominant heterozygous | (AG vs. GG) | 1.13 | 1.05–1.23 | 0.002 | |||
| Codominant homozygous | (AA vs. GG) | 1.34 | 1.19–1.51 | <0.001 | |||
| García-Lozano JR, 2013 | Allelic | (A vs. G) | 1.02 | 0.42–2.42 | 0.964 | ||
| Dominant | (AG + AA vs. GG) | NA | |||||
| Recessive | (AA vs. AG + GG) | ||||||
| Codominant heterozygous | (AG vs. GG) | ||||||
| Codominant homozygous | (AA vs. GG) | ||||||
| Shao S, 2014 | Allelic* | (A vs. G) | 1.32 | 1.04–1.69 | 0.021 | ||
| Dominant | (AG + AA vs. GG) | 1.41 | 1.08–1.84 | 0.010 | |||
| Recessive | (AA vs. AG + GG) | 1.52 | 1.13–2.05 | 0.006 | |||
| Codominant heterozygous | (AG vs. GG) | 1.28 | 0.97–1.70 | 0.077 | |||
| Codominant homozygous | (AA vs. GG) | 1.78 | 1.26–2.52 | 0.001 | |||
| Feng ZJ, 2015 | Allelic | (A vs. G) | 1.30 | 1.12–1.50 | <0.001 | ||
| Dominant | (AG + AA vs. GG) | 1.55 | 1.32–1.82 | <0.001 | |||
| Recessive | (AA vs. AG + GG) | 1.25 | 1.05–1.49 | 0.010 | |||
| Codominant heterozygous | (AG vs. GG) | 1.51 | 1.28–1.79 | <0.001 | |||
| Codominant homozygous | (AA vs. GG) | 1.62 | 1.32–1.99 | <0.001 | |||
| Li X, 2016 | Allelic* | (A vs. G) | 1.41 | 1.16–1.70 | <0.001 | ||
| Dominant | (AG + AA vs. GG) | 1.48 | 1.22–1.78 | <0.001 | |||
| Recessive | (AA vs. AG + GG) | 1.78 | 1.36–2.35 | <0.001 | |||
| Codominant heterozygous | (AG vs. GG) | 1.34 | 1.10–1.64 | 0.003 | |||
| Codominant homozygous | (AA vs. GG) | 2.09 | 1.56–2.81 | <0.001 | |||
| SNP rs760426 ( A > G ) | Terao C, 2011 | A | Allelic* | (G vs. A) | 1.23 | 1.10–1.37 | <0.001 |
| Dominant | (GG + GA vs. AA) | 1.16 | 1.04–1.29 | 0.007 | |||
| Recessive* | (GG vs. GA + AA) | 1.66 | 1.43–1.94 | <0.001 | |||
| Codominant heterozygous* | (GA vs. AA) | 1.03 | 0.92–1.16 | 0.582 | |||
| Codominant homozygous* | (GG vs. AA) | 1.69 | 1.43–2.00 | <0.001 | |||
| B | Allelic* | (G vs. A) | 1.13 | 1.02–1.25 | 0.011 | ||
| Dominant | (GG + GA vs. AA) | 1.19 | 1.08–1.31 | <0.001 | |||
| Recessive | (GG vs. GA + AA) | 1.15 | 1.00–1.32 | 0.047 | |||
| Codominant heterozygous | (GA vs. AA) | 1.17 | 1.06–1.30 | 0.002 | |||
| Codominant homozygous | (GG vs. AA) | 1.25 | 1.08–1.46 | 0.003 | |||
| C | Allelic* | (G vs. A) | 1.16 | 1.08–1.26 | <0.001 | ||
| Dominant | (GG + GA vs. AA) | 1.18 | 1.09–1.27 | <0.001 | |||
| Recessive | (GG vs. GA + AA) | 1.19 | 1.07–1.32 | 0.001 | |||
| Codominant heterozygous | (GA vs. AA) | 1.15 | 1.06–1.25 | 0.001 | |||
| Codominant homozygous | (GG vs. AA) | 1.29 | 1.15–1.44 | <0.001 | |||
| Shao S, 2014 | Allelic* | (G vs. A) | 1.25 | 0.98–1.60 | 0.062 | ||
| Dominant | (GG + GA vs. AA) | 1.19 | 0.92–1.55 | 0.171 | |||
| Recessive | (GG vs. GA + AA) | 1.55 | 1.16–2.08 | 0.003 | |||
| Codominant heterozygous | (GA vs. AA) | 1.04 | 0.79–1.38 | 0.741 | |||
| Codominant homozygous | (GG vs. AA) | 1.60 | 1.15–2.24 | 0.006 | |||
| Feng ZJ, 2015 | Allelic* | (G vs. A) | 1.87 | 1.09–2.45 | 0.074 | ||
| Dominant | (GG + GA vs. AA) | NA | |||||
| Recessive | (GG vs. GA + AA) | ||||||
| Codominant heterozygous | (GA vs. AA) | ||||||
| Codominant homozygous | (GG vs. AA) | ||||||
| Li X, 2016 | Allelic* | (G vs. A) | 1.25 | 1.04–1.52 | 0.018 | ||
| Dominant | (GG + GA vs. AA) | 1.32 | 1.10–1.59 | 0.003 | |||
| Recessive | (GG vs. GA + AA) | 1.36 | 1.05–1.77 | 0.020 | |||
| Codominant heterozygous | (GA vs. AA) | 1.26 | 1.03–1.54 | 0.020 | |||
| Codominant homozygous | (GG vs. AA) | 1.54 | 1.16–2.04 | 0.003 | |||