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. 2017 Oct 26;7:14076. doi: 10.1038/s41598-017-14292-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HFD is required for the exacerbation of psoriatic dermatitis. (a) Comparison of body weight in WT mice fed with either ND or HFD and ob/ob mice fed with ND. (b) Fold induction of Il17a mRNA in the skin of WT mice fed with ND or HFD and ob/ob mice fed with ND in the steady state, as analyzed by qRT-PCR. Results are presented relative to those of WT with ND. The average mRNA expression level in ND-fed WT mice is set as 1. (c,d) Flow cytometric analysis of T cell subsets (c) and the number of γδ TCR^mid γδ T cells (d) in the whole ear skin of WT mice fed with either ND or HFD and ob/ob mice fed with ND in the steady state. (e) IMQ-induced psoriatic dermatitis in WT mice fed with either ND or HFD and ob/ob mice fed with ND assessed as change in ear swelling. Results are expressed as the mean ± SD (e) and SEM (a–c). p-values were obtained by one-way ANOVA. *p ≤ 0.05. Data are from one experiment, representative of four independent experiments with three to four mice (a,c,d), three experiments with four mice (e). Data are pooled from three experiments with three to four mice (b).