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. 2017 Oct 26;7:14089. doi: 10.1038/s41598-017-14372-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Putative ligand-binding sites of TlpC LBD. (a) Molecular surface of TlpC LBD with cavities and pockets coloured orange. The stalk helix is coloured pink, the membrane-distal module – light blue and the membrane-proximal module – cyan. (b) Structure superposition of membrane-distal modules of TlpC (pink) and Tlp3 (light blue) highlighting differences in position of helix α3 and β3-β4-tongue (coloured hot pink and blue in TlpC and Tlp3, respectively). Isoleucine bound to the membrane-distal module of Tlp3 is shown as grey sticks.