Table 2.
Steroid hormone profiling measured with LC-MS/MS, and free androgen index (FAI) in PCOS patients and controls.
| PCOS (n = 1044) | Control (n = 366) | |||||
|---|---|---|---|---|---|---|
| BMI < 25 (n = 350) | 25 ≤ BMI < 30 (n = 312) | BMI ≥ 30 (n = 382) | BMI < 25 (n = 203) | 25 ≤ BMI < 30 (n = 32) | BMI ≥ 30 (n = 131) | |
| Steroid hormones profiling (ng/ml) | ||||||
| DHEAS | 1170.0 (798.5, 1595.0)ab | 1040.0(735.0, 1470.0) | 1080.0 (729.0, 1440.0)a | 999.0 (728.5, 1392.5)b | 918.0 (737.0, 1220.0) | 930.5 (713.0, 1297.5) |
| 17-hydropregnenolone | 1.380 (0.723, 2.750)ab | 1.150 (0.618, 2.150)c | 1.095 (0.576, 2.023)a | 0.889 (0.377, 1.750)b | 0.816 (0.435, 1.620)c | 1.180 (0.605, 2.710) |
| Aldosterone | 0.038 (0.022, 0.066) | 0.041 (0.023,0.064) | 0.038 (0.024, 0.069) | 0.037 (0.024, 0.059) | 0.038 (0.028, 0.059) | 0.037 (0.021, 0.064) |
| Corticosterone | 1.770 (0.977, 2.990) | 1.425 (0.856, 2.523) | 1.515 (0.927, 2.983) | 1.550 (0.960, 2.670) | 1.580 (1.088, 2.090) | 1.750 (0.953, 3.070) |
| Cortisol | 88.80 (60.28, 124.00)a | 82.40 (56.50, 114.00)b | 85.49 (56.58, 118.66) | 73.50 (53.10, 102.00)a | 68.00 (55.43, 88.90)b | 81.60 (55.80, 117.00) |
| Cortisone | 29.50 (23.98, 36.85) | 28.30 (22.24, 38.20) | 30.19 (22.93, 39.45) | 29.30 (23.00, 38.50) | 31.30 (22.50, 39.33) | 29.70 (21.50, 41.00) |
| Estrone | 0.718 (0.457, 1.120)ac | 0.767 (0.455, 1.280)b | 0.551 (0.366, 0.841)abd | 0.497 (0.320, 0.769)c | 0.471 (0.310, 1.183) | 0.712 (0.379, 1.100)d |
| Pregnenolone | 10.600 (6.150, 20.600) | 13.350 (6.788, 23.775) | 12.100 (7.535, 22.550) | 12.370 (7.385, 21.424) | 12.450 (7.350, 18.975) | 13.700 (8.860, 21.300) |
| Deoxycorticosterone | 0.038 (0.025, 0.059) | 0.035 (0.022, 0.050)a | 0.033 (0.021, 0.055) | 0.040 (0.028, 0.060) | 0.041 (0.029, 0.054)a | 0.036 (0.023, 0.065) |
| 17-hydroprogesterone | 0.331 (0.196, 0.744)ac | 0.325 (0.188, 0.668)b | 0.231 (0.130, 0.421)ab | 0.270 (0.116, 0.710)c | 0.273 (0.097, 0.772) | 0.184 (0.074, 0.475) |
| 11-deoxycortisol | 0.337 (0.176, 0.589)a | 0.284 (0.164, 0.497)b | 0.300 (0.183, 0.493) | 0.250 (0.150, 0.390)a | 0.187 (0.094, 0.384)b | 0.322 (0.143, 0.535) |
| Progesterone | 0.277 (0.139, 0.984)a | 0.262 (0.131, 0.825)b | 0.154 (0.070, 0.690)ab | 0.476 (0.121, 1.800) | 0.213 (0.070, 3.315) | 0.218 (0.070, 0.977) |
| Androstenedione | 2.290 (1.683, 3.183)a | 2.225 (1.670, 3,148)b | 2.525 (1.780, 3.218)c | 1.830 (1.360, 2.260)a | 1.950 (1.518, 2.298)b | 1.860 (1.430, 2.610)c |
| Testosterone | 0.434 (0.310, 0.603)b | 0.420 (0.291, 0.570)ac | 0.479 (0.347, 0.661)ad | 0.328 (0.260, 0.416)b | 0.338 (0.261, 0.441)c | 0.345 (0.248, 0.446)d |
| Free androgen index (FAI) | ||||||
| FAI | 1.37 (0.81, 2.19)ade | 1.86 (1.16, 3.01)bdf | 2.82 (1.75, 4.67)cef | 0.55 (0.39, 0.76)a | 0.77 (0.49, 1.09)b | 1.77 (0.91, 2.86)c |
Data are presented as median (25,75 percentile). abcdefThe same superscripts indicate a statistically significant difference (P < 0.05) between pairs.