Table 3.
Enzyme activity evaluation in PCOS patients and controls.
| Enzyme | Product/precursor ratio | PCOS (n = 1044) | Control (n = 366) | ||||
|---|---|---|---|---|---|---|---|
| BMI < 25 (n = 350) | 25 ≤ BMI < 30 (n = 312) | BMI ≥ 30 (n = 382) | BMI < 25 (n = 203) | 25 ≤ BMI < 30 (n = 32) | BMI ≥ 30 (n = 131) | ||
| P450c17 | 17-OHP5/P5 | 0.120 (0.057, 0.304)abc | 0.093 (0.041, 0.204)a | 0.088 (0.044, 0.198)b | 0.082 (0.029, 0.192)c | 0.096 (0.029, 0.162) | 0.099 (0.046, 0.221) |
| P450c17 | 17-OHP/P | 1.087 (0.370, 2.565)a | 1.170 (0.406, 2.371) | 1.302 (0.322, 3.153) | 0.500 (0.136, 1.577)a | 0.789 (0.203, 3.038) | 0.997 (0.321, 2.143) |
| P450c17 | AD2/17-OHP | 6.999 (2.971, 11.750)a | 7.747 (3.468, 12.580)b | 11.296 (7.055, 17.476)ab | 7.627 (2.773, 13.862) | 5.684 (2.832, 17.910) | 11.333 (3.473, 16.412) |
| P450c21 | DOC/P | 0.120 (0.043, 0.253)a | 0.116 (0.046, 0.232)b | 0.207 (0.050, 0.474)ab | 0.067 (0.022, 0.311) | 0.220 (0.022, 0.501) | 0.154 (0.042, 0.443) |
| P450c21 | S/17-OHP | 0.883 (0.384, 2.154)a | 0.773 (0.378, 1.824)b | 1.362 (0.608, 2.795)ab | 0.810 (0.330, 2.296) | 0.888 (0.222, 2.554) | 1.224 (0.503, 3.133) |
| P450c11β | B/DOC | 46.98 (28.76, 74.44)a | 44.73 (28.26, 71.36) | 48.50 (28.05, 81.60) | 39.00 (21.67, 69.33)a | 33.88 (23.01, 67.74) | 53.15 (24.55, 81.33) |
| P450c11β | F/S | 242.5 (151.7, 409.5)a | 274.4 (166.0, 397.8) | 255.3 (170.9, 383.2) | 293.2 (198.4, 427.6)a | 295.9 (216.5, 465.7) | 259.8 (178.0, 396.6) |
| P450aro | E1/AD2 | 0.320 (0.175, 0.563)a | 0.322 (0.175, 0.623)b | 0.219 (0.133, 0.391)abc | 0.280 (0.172, 0.457) | 0.263 (0.183, 0.516) | 0.347 (0.191, 0.661)c |
| P450c11AS | Aldo/B | 0.022 (0.010, 0.045) | 0.027 (0.013, 0.053) | 0.025 (0.012, 0.047) | 0.023 (0.011, 0.041) | 0.027 (0.017, 0.051) | 0.021 (0.008, 0.040) |
| 3βHSD2 | P/P5 | 0.030 (0.011, 0.112)a | 0.022 (0.008, 0.086)b | 0.015 (0.005, 0.076)ab | 0.036 (0.009, 0.152) | 0.014 (0.005, 0.246) | 0.018 (0.006, 0.089) |
| 3βHSD2 | 17-OHP/17-OHP5 | 0.253 (0.113, 0.591)ac | 0.294 (0.143, 0.583)b | 0.194 (0.099, 0.442)ab | 0.380 (0.155, 0.684)c | 0.317 (0.111, 1.424) | 0.204 (0.923, 0.404) |
| 11βHSD2 | C/F | 0.355 (0.244, 0.490)a | 0.377 (0.259, 0.506)b | 0.382 (0.256, 0.563) | 0.389 (0.318, 0.556)a | 0.470 (0.345, 0.632)b | 0.386 (0.257, 0.531) |
| 17βHSD3 | T/AD2 | 0.187 (0.153, 0.237) | 0.184 (0.150, 0.221) | 0.190 (0.157, 0.236)a | 0.187 (0.162, 0.213) | 0.184 (0.148, 0.233) | 0.176 (0.140, 0.218)a |
Data are presented as median (25,75 percentile). abcdefThe same superscripts indicate a statistically significant difference (P < 0.05) between pairs.