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. 2017 Oct 26;7:14153. doi: 10.1038/s41598-017-14190-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Association rate constants of NS SOS protein molecules with membrane components. (a) Successive images on the cell surface showing the appearance (arrows) and disappearance (arrowhead) of single SOS molecules. (b,c) Relative association rate constants (k_on) of SOS molecules with the cell surface. The molecules contained the REM(−) mutation (c) or did not (b). R1131KΔH contained the REM domain but the H domain was deleted. The appearance rate of fluorescent SOS molecules per unit area of the cell surface was normalized to the fluorescence intensity in the cytoplasm and plotted as values relative to that of WT SOS before EGF stimulation (time 0). Averages of 5–10 cells with SE. Asterisks indicate statistical significance relative to the densities in WT or WT REM(−) at the indicated times (p < 0.05 on Mann–Whitney test).