Table 5.
Subjects with at least 3 mutations in the Gag P2/NC cleavage site.
| Sample ID | P2/NC | PIs DRMs | ||
|---|---|---|---|---|
| Cleavage site mutations | AMs | Treatment | Subtypes | |
| NA2CMR010 | T375A, I376V, G381S | K20I | 3TC-AZT-NVP | 02_AG |
| NA2CMR013 | T375A, I376V, G381S | K20I | Naïve | 02_AG |
| NA2CMR115 | A374S, T375S, R380K, G381S | K20I, K43T | Naïve | 13_cpx |
| NA2CMR147 | A374N, T375S, I376V, G381S | K20I, L10V | Naïve | 02_AG |
| NA2CMR151 | S373Q, T375G, I376V, G381S | K20I, L10I | 3TC-AZT-NVP | 02_AG |
| NA2CMR176 | A374T, T375G, I376V, G381S | K20I | 3TC-AZT-NVP | 02_AG |
| NA2CMR216 | S373A, A374S, R380K, G381S | L10V | 3TC-AZT-NVP | F2 |
| NACMR071 | A374S, T375N, I376V, G381S | K20I | Naïve | 02_AG |
| NACMR165 | S373Q, A374T, I376V | * | Naïve | 02_AG |
| NACMR052 | S373T, A374G, I376V, G381S | K20I, E35G | Naïve | 02_AG |
| NACMR056 | S373A, A374S, T375A | K20I | Naïve | 02_AG |
| NACMR086 | S373Q, A374T, T375S, I376V | K20I, L33F | Naïve | 02_AG |
PIs: protease inhibitors; DRMs: drug resistance mutations; AMs: accessory (secondary) mutations; AZT: zidovudine; 3TC: lamivudine; NVP: nevirapine; 02_AG: HIV-1 CRF02_AG; 13_cpx: CRF13_cpx. *Sample not amplified.