Table 2.

Univariate prognostic factors of overall survival and progression free survival

Demographic and clinical factors (n = 103)		Frequency (%)	5-year OS ± SE	10-year OS ± SE	OS p value*	5-year PFS ± SE	10-year PFS ± SE	PFS p value*
Institution	DFCI/BCH	48 (47)	63 ± 7	48 ± 8	0.6	43 ± 7	30 ± 7	0.8
	LCH	55 (53)	71 ± 6	52 ± 9		36 ± 7	27 ± 7
Age at diagnosis	<3 years old	43 (42)	73 ± 7	57 ± 8	0.5	40 ± 7	32 ± 7	0.9
	≥3 years old	60 (58)	63 ± 6	46 ± 7		39 ± 6	27 ± 6
Gender	Male	49 (48)	68 ± 8	47 ± 8	0.6	36 ± 7	25 ± 6	0.3
	Female	54 (52)	67 ± 7	54 ± 7		41 ± 7	33 ± 7
Tumor location	Infratentorial	78 (76)	65 ± 6	51 ± 6	0.7	41 ± 6	32 ± 5	0.5
	Supratentorial	25 (24)	74 ± 9	45 ± 12		34 ± 10	19 ± 8
Tumor grade	II	75 (73)	71 ± 5	56 ± 7	0.026	42 ± 6	30 ± 6	0.5
	III	28 (27)	57 ± 10	35 ± 16		30 ± 9	25 ± 8
Site of recurrencea	Local only	51/69 (74)	60 ± 7	39 ± 7	0.2	14 ± 5	2 ± 2	0.7
	Intracranial dissemination only	5/69 (7)	75 ±  22	50 ± 25		40 ± 22	20 ± 18
	Distant spine only	4/69 (6)	50 ± 25	50 ± 25		25 ± 22	25 ± 22
	Local + Distant spine	9/69 (13)	44 ± 17	11 ± 10		22 ± 14	0
Extent of resection	GTR	64	75 ± 5	61 ± 7	0.002	48 ± 6	36 ± 6	0.0022
	STR	39	54 ± 8	32 ± 8		24 ± 7	16 ± 6
Treatment	XRT only	41/101	79 ± 7	73 ± 7	<0.0001	50 ± 8	42 ± 8	0.0016
	Chemo only	11/101	73 ± 13	45 ± 15		27 ± 13	18 ± 12
	Chemo + XRT	40/101	51 ± 8	26 ± 8		26 ± 7	14 ± 6
	Observation	9/101	88 ± 12	88 ± 12		63 ± 17	63 ± 17

Histopathologic features (n = 48)		Frequency (%)	5-year OS ± SE	10-year OS ± SE	OS p value*	5-year PFS ± SE	10-year PFS ± SE	PFS p value*
Architecture	Classic (WHO Grade II)	13	85 ± 10	67 ± 14	0.2	62 ± 13	44 ± 14	0.4
	Anaplastic (WHO grade III)	35	49 ± 11	38 ± 11		32 ± 10	27 ± 9
Necrosis	No	11	82 ± 12	61 ± 15	0.1	36 ± 15	24 ± 14	0.8
	Yes	37	57 ± 8	44 ± 9		45 ± 8	32 ± 8
Vascular proliferation	No	19	72 ± 11	61 ± 12	0.18	50 ± 12	39 ± 12	0.4
	Yes	29	57 ± 9	38 ± 10		38 ± 9	25 ± 9
P53 status	Negative	20	74 ± 10	57 ± 12	0.5	55 ± 11	33 ± 11	0.7
	Positive	28	54 ± 10	41 ± 10		34 ± 9	29 ± 9
Blc-2 status	Negative	6	100	50 ± 25	0.3	67 ± 19	44 ± 22	0.08
	Positive	42	58 ± 8	47 ± 8		39 ± 8	28 ± 7
MIB-1 LI	<20.5	31	74 ± 8	49 ± 10	0.9	52 ± 9	32 ± 9	0.8
	≥20.5	17	44 ± 12	44 ± 12		25 ± 11	25 ± 11
Topo-II alpha expression	<9.4	34	75 ± 8	54 ± 9	0.052	49 ± 9	32 ± 8	0.2
	≥9.4	14	36 ± 13	36 ± 13		29 ± 12	29 ± 12
Mitotic index	≤10	40	67 ± 8	49 ± 8	0.3	45 ± 8	31 ± 8	0.4
	>10	8	43 ± 19	43 ± 19		29 ± 17	29 ± 17
Cyclin D expression	Negative	12	72 ± 14	48 ± 17	0.5	58 ± 14	29 ± 14	0.4
	Positive	36	60 ± 8	47 ± 8		37 ± 8	31 ± 8

^aRestricted to patients who relapsed

*p value of log rank test