Table 2.
Study outcome, type and timing of radiotherapy and number of ischemic stroke
| Authors | N radiation as primary treatment (%) | N radiation at recurrence (%) | Median dose of radiotherapy, Gy (range) | Radiotherapy: median no of fractions (range) | EQD2, Gy (α/β = 2) | N of Ischemic stroke/total N of patients (%) |
|---|---|---|---|---|---|---|
| Bir et al. [17] | 38 (71.7) | 19 (35.8) | 15 (12–20) | 1 | 63.8 | 0/57 (0) |
| Diallo et al. [18] | 4a (11.8) | 30 (88.2) | 50 | 27 | 50.0 | 0/34 (0) |
| Elborsson et al. [19] | Ns | Ns | 40 | 20 | 40.0 | 1/18 (5.6) |
| Flickinger et al. [20] | Ns | Ns | 4180 (35.72–62.32) | 22 (20–25) | 40.8 | 7/156 (4.5) |
| Hashimoto et al. [21] | Ns | Ns | 40–60 | (20–25) | 40.0–66.0 | 10/139 (7.2) |
| Inoue et al. [22] | Ns | Ns | Mean 20.2 (9–42) | 1 | 110.0 | 0/35 (0) |
| Olsson et al. [23] | Ns | Ns | Ns | Ns | NA | 7/104 (6.7) |
| Sattler et al. [5] | Ns | Ns | 45–49 | 25b | 42.8 | 10/236 (4.2) |
| Schalin-Jantti et al. [24] | 18 (60.0) | 12 (40.0) | 45 (45–54) | 25 (25–30) | 42.8 | 0/30 (0) |
| van Varsseveld et al. [6] | Ns | Ns | Mean 45.6c | 25–30 | 42.8 | 53/456 (11.6) |
| Vargas et al. [25] | Ns | Ns | Mean 52 (50–57) | 25 | 53.8 | 0/51 (0) |
N number, Gy gray, EQD2 equivalent dose in 2 Gy fractions, Ns not stated, NA not applicable
aAfter failure of medical treatment
bMost patients received 25 × 1.8 Gy, specific no. of patients not reported
cUnknown in 104 patients