Table 3.
Associations between BMI gain during different periods of adulthood and hip modes 1 to 6 at age 60–64 in the MRC NSHD, by sex.
| Interval of BMI change (age (y)) | Men (n = 544) |
P value† | Women (n = 646) |
P value† |
|---|---|---|---|---|
| β (95%CI) | β (95%CI) | |||
| HM 1 | ||||
| 20 to 36 | − 0.025 (− 0.115, 0.065) | 0.6 | − 0.002 (− 0.077, 0.072) | > 0.9 |
| 36 to 53 | 0.028 (− 0.064, 0.119)a | 0.6 | 0.031 (− 0.043, 0.104) | 0.4 |
| 53 to 60–64⁎ | − 0.109 (− 0.200, − 0.018) | 0.02 | 0.009 (− 0.067, 0.086) | 0.8 |
| HM 2 | ||||
| 20 to 36 | 0.149 (0.056, 0.242)b | 0.002 | 0.104 (0.028, 0.18) | 0.007 |
| 36 to 53 | 0.113 (0.017, 0.208) | 0.020 | 0.108 (0.033, 0.183) | 0.005 |
| 53 to 60–64 | 0.014 (− 0.08, 0.109) | 0.8 | 0.083 (0.005, 0.16) | 0.04 |
| HM 3 | ||||
| 20 to 36 | 0.006 (− 0.08, 0.092) | 0.9 | 0.097 (0.025, 0.169) | 0.009 |
| 36 to 53 | − 0.0005 (− 0.089, 0.088) | > 0.9 | 0.006 (− 0.066, 0.077) | 0.9 |
| 53 to 60–64 | − 0.011 (− 0.099, 0.077) | 0.8 | 0.063 (− 0.012, 0.137) | 0.1 |
| HM 4 | ||||
| 20 to 36⁎ | − 0.094 (− 0.189, 0.001) | 0.05 | 0.035 (− 0.035, 0.106) | 0.3 |
| 36 to 53 | − 0.054 (− 0.151, 0.043) | 0.3 | 0.002 (− 0.067, 0.072) | 0.9 |
| 53 to 60–64 | 0.014 (− 0.082, 0.111) | 0.8 | 0.012 (− 0.060, 0.085) | 0.7 |
| HM 5 | ||||
| 20 to 36 | 0.015 (− 0.08, 0.111) | 0.7 | 0.015 (− 0.058, 0.089) | 0.7 |
| 36 to 53 | 0.023 (− 0.075, 0.121) | 0.6 | 0.007 (− 0.066, 0.08) | 0.8 |
| 53 to 60–64 | − 0.023 (− 0.12, 0.074) | 0.6 | 0.029 (− 0.047, 0.104) | 0.5 |
| HM 6 | ||||
| 20 to 36 | 0.004 (− 0.08, 0.089) | 0.9 | − 0.001 (− 0.079, 0.077) | > 0.9 |
| 36 to 53 | − 0.014 (− 0.1, 0.072) | 0.7 | 0.004 (− 0.074, 0.081) | 0.9 |
| 53 to 60–64 | 0.089 (0.003, 0.174) | 0.04 | − 0.008 (− 0.088, 0.072) | 0.8 |
Notes: The coefficients from these models can be interpreted as the influence of change in BMI in the specified period above or below that expected given earlier BMI on HM scores.
Coef. > 0: greater gain in BMI (i.e. + 1 SD in BMI residuals) in the specified age interval associated with 1SD increase in the hip mode score.
Coef. < 0: greater gain in BMI (i.e. − 1 SD in BMI residuals) in the specified age interval associated with 1SD decrease in the hip mode score.
From Wald test.
P value for sex interaction ≤ 0.05.
Association between weight gain from 36 to 53 years and HM1 was larger than the association from 53 to 60–64years, (Wald test p value of the difference between the two coefficients = 0.04).
Association between weight gain from 20 to 36 years and HM2 was larger than the association from 53 to 60–64years (Wald test p value of the difference between the two coefficients = 0.05).