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. 2016 Jul 12;22(11):1576–1584. doi: 10.1038/mp.2016.103

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Phenotypes of mice with Atg7-deficient microglia. (a) Sagittal images of Atg7^fl/+;Lyz2^Cre/+;ROSA26-tdTomato mouse brain at postnatal day 7 stained with an antibody against Iba-1 (green) and Hoechst 33342 (blue). Tomato expression (red) was detected in all brain regions. Scale bar=500 μm. (b) Most of the Tomato expression (red) was co-localized with Iba-1-positive microglia (green). Scale bar=20 μm. (c) Atg7 protein was not detected in the lysate of primary microglia cultures or in peritoneal macrophages collected from Atg7^fl/fl;Lyz2-Cre mouse. (d) Body and brain weights of adult Atg7^fl/fl;Lyz2-Cre mice were similar to those of controls (n=12 for each group).