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. 2017 Jun 12;36(41):5681–5694. doi: 10.1038/onc.2017.177

Figure 8.

Figure 8

High levels of α6-integrin, FOSL1 or αV-integrin expression correlate with aggressive phenotypes in mutant K-Ras-driven human cancers. (a) ITGA6, FOSL1 and ITGAV mRNA expression was determined from cancer cell lines with either WT K-Ras (n=522) or with K-Ras mutation (n=76) from the Garnett et al.42 cancer cell line data set. Gene expression intensity is shown as the log2 median-centered intensity, as reported in Oncomine.69 (b) Kaplan–Meier plots showing the survival of pancreatic adenocarcinoma patients (PAAD) and (c) lung adenocarcinoma (LUAD) patients with either high (top 10% highest expression; n=20 for PAAD; n=44 for LUAD) or low (bottom 10% lowest expression; n=18 for PAAD; n=37 for LUAD) expression of ITGA6, FOSL1 and ITGAV. (queried from TCGAbrowser45).