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. 2017 Aug 30;14(5):4547–4553. doi: 10.3892/etm.2017.5070

Figure 3.

Figure 3.

mRNA expression levels of (A) TYR, (B) TRP-1 and (C) TRP-2 in A375 cells were detected by reverse transcription-quantitative polymerase chain reaction in (a) the control group, (b) the estradiol group, (c) the wogonin group and (d) the wogonin + ICI182780 group. β-actin bands are shown on the right of the ladder ICI182780, estrogen inhibitor; TYR, tyrosinase; TRP-1, tyrosinase related protein 1; TRP-2, tyrosinase related protein 2; ERK1, extracellular signal-regulated kinase 1; ERK2, extracellular signal-regulated kinase 2; JNK2, c-Jun N-terminal kinase 2; control group, cells in the presence of Dulbecco's modified Eagle medium without treatment; estradiol group, cells in the presence of estradiol (10−3 µmol/l); wogonin group, cells in the presence of wogonin (10 µmol/l); wogonin + ICI182780 group, cells in the presence of ICI182780 (1 µmol/l) and 10 µmol/l of wogonin.