Table III.

Effects of wogonin on the melanin synthesis of A375 cells.

Group (µmol/l)	OD	OD treatment group/OD control group (%)
Control group (−)	0.138±0.009	100.00
Estradiol group (10−3)	0.167±0.006a	121.90a
Wogonin group (10)	0.063±0.013a	45.99a
Wogonin group (10) + ICI182780 (1)	0.106±0.003a,b	77.37a,b
Wogonin group (10) + U0126 (10)	0.085±0.005a,b	62.04a,b

Data are presented as the (mean ± standard deviation, n=4)

^aP<0.01 vs. the control group

^bP<0.01 vs. the wogonin group. ICI182780, estrogen inhibitor; U0126, extracellular signal-regulated kinase inhibitor; OD, optical density.