Figure 3.

Delivery of miR-155 shRNA lentiviral vectors suppresses the development of airway hyperresponsiveness. Mice were exposed to nebulized saline, followed by increasing doses (3–25 mg/ml) of nebulized methacholine for 3 min each. Breathing indices were measured for 3 min after each nebulization and enhanced pause values were determined. n=4–5 mice/group. *P<0.01 vs. the saline group; ^#P<0.05 vs. Mock group. OVA, ovalbumin; miR-155, microRNA-155; shRNA, short hairpin RNA; R_aw, airway resistance.