Table 3. In vitro activities of antifungal agents tested against 251 non-albicans Candida isolates obtained from patients with candidemia according to the Clinical and Laboratory Standards Institute recommendations.
| Non-albicans Candida species | MIC range (mg/L) | MIC50(mg/L) | MIC90 (mg/L) | Number of isolates (%) | |||
|---|---|---|---|---|---|---|---|
| S | SDD | I | R | ||||
| C. tropicalis (n=122) | |||||||
| Amphotericin B | 0.25–2 | 0.5 | 1 | — | — | — | — |
| Fluconazole | 0.25–128 | 2 | 8 | 87 (71.3) | 18 (14.8) | — | 17 (13.9) |
| Voriconazole | 0.015–4 | 0.25 | 1 | 60 (49.2) | 49 (40.2) | — | 13 (10.7) |
| Posaconazole | 0.015–2 | 0.25 | 0.5 | — | — | — | — |
| Itraconazole | 0.06–1 | 0.25 | 0.5 | — | — | — | — |
| Caspofungin | 0.015–>8 | 0.06 | 0.25 | 118 (96.7) | — | 1 (0.8) | 3 (2.5) |
| Micafungin | 0.015–2 | 0.03 | 0.03 | 118 (96.7) | — | 1 (0.8) | 3 (2.5) |
| Anidulafungin | 0.03–1 | 0.12 | 0.25 | 119 (97.5) | — | 1 (0.8) | 2 (1.6) |
| Flucytosine | ≤0.06–>64 | ≤0.06 | 0.12 | — | — | — | — |
| C. glabrata (n=96) | |||||||
| Amphotericin B | ≤0.12–4 | 0.5 | 1 | — | — | — | — |
| Fluconazole | 0.5–>256 | 16 | 32 | — | 93 (96.7) | — | 3 (3.1) |
| Voriconazole | ≤0.008–4 | 0.5 | 1 | — | — | — | — |
| Posaconazole | 0.015–>8 | 1 | 2 | — | — | — | — |
| Itraconazole | 0.03–2 | 0.5 | 1 | — | — | — | — |
| Caspofungin | 0.03–1 | 0.12 | 0.25 | 80 (83.3) | — | 14 (14.6) | 2 (2.1) |
| Micafungin | ≤0.008–1 | 0.015 | 0.015 | 90 (93.8) | — | 1 (1) | 5 (5.2) |
| Anidulafungin | ≤0.015–1 | 0.06 | 0.12 | 90 (93.8) | — | 1 (1) | 5 (5.2) |
| Flucytosine | ≤0.06–0.5 | ≤0.06 | 0.12 | — | — | — | — |
| C. parapsilosis (n=33) | |||||||
| Amphotericin B | 0.25–1 | 0.5 | 0.5 | — | — | — | — |
| Fluconazole | 0.25–8 | 1 | 2 | 30 (90.9) | 1 (3) | — | 2 (6.1) |
| Voriconazole | ≤0.008–0.25 | 0.015 | 0.03 | 32 (97) | 1 (3) | — | 0 (0) |
| Posaconazole | 0.015–0.12 | 0.03 | 0.06 | — | — | — | — |
| Itraconazole | 0.03–0.25 | 0.06 | 0.12 | — | — | — | — |
| Caspofungin | 0.25–1 | 0.5 | 0.5 | 33 (100) | — | 0 (0) | 0 (0) |
| Micafungin | 0.25–2 | 1 | 2 | 33 (100) | — | 0 (0) | 0 (0) |
| Anidulafungin | 0.25–2 | 1 | 2 | 33 (100) | — | 0 (0) | 0 (0) |
| Flucytosine | ≤0.06–0.5 | 0.12 | 0.25 | — | — | — | — |
Abbreviations: intermediate, I; minimum inhibitory concentrations for 50% and 90% of the organisms, respectively, MIC50/90; susceptible, S; susceptible dose-dependent, SDD; resistant, R.
Data are presented as frequency with percentage (%).