Figure 7.
In vivo protection and therapeutic activity of anti-ZIKV mAbs against ZIKV infection. Four- to eight-week-old AG6 mice were inoculated with 105 PFU of ZIKV by i.p. route. At 12 h post ZIKV infection or 4 h before 103 PFU ZIKV infection, mice were administered m301 or a cocktail of m301 and m302 via i.p. injection. (A, C) Mortality of AG6 mice was monitored after infection. (B, D) Mice were weighed daily, and weights are expressed as the percentage of body weight prior to infection. Abbreviations: intraperitoneal, i.p.; monoclonal antibodies, mAbs; plaque-forming units, PFU; Zika virus, ZIKV.