Table 1. Genetic analysis of the heavy and light chain variable regions of ZIKV DIII-specific antibodies.
| mAb | Variable region | Variable region identity (%) | D | J | CDR3 |
|---|---|---|---|---|---|
| VH | |||||
| m301 | HV3-30*03 | 97.57 | D6-6*01 | J4*02 | AKEVGRSYFDY |
| m302 | HV3-30*04 | 98.26 | D7-27*01 | J6*02 | AREIGDYYYYGMDV |
| m303 | HV3-64D*06 | 100.00 | D2-2*01 | J4*02 | VFPSLGYCSSTSCYPPS |
| m304 | HV3-30*03 | 98.96 | D3-10*01 | J3*02 | ARQRGAFDI |
| VL | |||||
| m301 | KV4-1*01 | 97.64 | J1*01 | QQYYSTPQT | |
| m302 | KV3-11*01 | 94.98 | J4*01 | QQSYSTPLT | |
| m303 | LV2-14*01 | 98.26 | J3*02 | SSYTSSSSWV | |
| m304 | KV1-12*01 | 97.85 | J3*01 | QKYNSAPLT | |
Abbreviations: complementarity-determining region, CDR; monoclonal antibody, mAb; heavy- and light-chain variable domains, VH and VL.