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. Author manuscript; available in PMC: 2017 Oct 27.
Published in final edited form as: Expert Rev Vaccines. 2017 May 2;16(6):601–611. doi: 10.1080/14760584.2017.1321482

Figure 1. Schematic representation of RVFV MP-12 strain genome structure.

Figure 1

Negative-sense RNA genome of the MP-12 vaccine is shown, including Small (S)-, Medium (M)-, and Large (L)-segments. A total of 23 mutations of the MP-12 strain compared to the parental ZH548 strain are also specified. When individual MP-12 mutations were introduced into the pathogenic ZH501 strain, the resulting mutant viruses displayed attenuation and/or temperature-sensitivity (ts) phenotypes, as summarized in the box under the genome schematics [61,98].