Myofibroblasts induce structural remodeling of cardiomyocytes. Fluorescence microscopy by confocal laser scanning. Protein organization at the myofibroblast (MF)–cardiomyocyte (CM). CM contact sites of vinculin. In the CM, vinculin is reorganized in strands parallel to the direction of the strain imposed by the MF. Modified by permission from Driesen RB, Verheyen FK, Dispersyn GD, Thone F, Lenders MH, Ramaekers FC, Borgers M. Structural adaptation in adult rabbit ventricular myocytes: Influence of dynamic physical interaction with fibroblasts. Cell Biochem Biophys. 2006;44:119–128.