Table 3.
Univariate and Multivariate Analysis of Local Failure
| Univariate Analysis | Multivariate Analysis | |||||
| HR | 95% CI | p-Value | HR | 95% CI | p-Value | |
| Age (years) | 0.998 | 0.981-1.015 | 0.7883 | - | - | - |
| Female v. Male | 0.706 | 0.490-0.490 | 0.0629 | - | - | - |
| Primary Tumor (v. Lung) Breast Melanoma Other |
0.837 1.567 1.441 |
0.555-1.264 0.925-2.654 0.752-2.761 |
0.3986 0.0951 0.0271 |
0.77 4.571 1.148 |
0.508-1.166 0.924-2.672 0.575-2.291 |
0.216 0.095 0.695 |
| Treatment Paradigm (v. SRS alone)<br/>WBRT then SRS<br/>SRS then WBRT | 0.531 0.438 |
0.349-0.807 0.248-0.774 |
0.003 0.0045 |
1.145 0.839 |
0.717-1.829 0.448-1.571 |
0.570 0.583 |
| Tumor Volume (cm3) | 5.039 | 3.491-7.274 | <0.001 | 5.167 | 3.409-7.832 | <0.001 |
| SRS Dose (Gy) | 0.952 | 0.906-1.001 | 0.0566 | - | - | - |
HR: Hazard Ratio, CI: Confidence Interval, SRS: stereotactic radiosurgery, WBRT: whole brain radiotherapy, cm3: cubic centimeter, Gy: Gray, Other: RCC, colorectal, head & neck, genitourinary.