Table 1.

Assigning outcomes for estimating treatment efficacy under current recommendations.

Source: WHO-2009 [3]

End-point for day X (X = 28 or 42)	Cumulative success or failure probability (Kaplan–Meier analysis)	Proportion (per-protocol analysis)
Adequate clinical and parasitological response at day X	Success	Success
Early treatment failure	Failure	Failure
Late clinical failure before day 7	Failure	Failure
Late clinical failure or late parasitological failure on or after day 7
Falciparum recrudescence	Failure	Failure
Falciparum reinfection	Censored day of reinfection	Excluded from analysis
Other species with falciparum recrudescence	Failure	Failure
Other species infection	Censored day of infection	Excluded from analysis
Undermined or indeterminate PCR	Excluded from PCR-corrected analysis	Excluded from analysis
Loss to follow-up	Censored last day of follow-up according to timetable	Excluded from analysis
Withdrawal and protocol violation	Censored last day of follow-up according to timetable before withdrawal or protocol violation	Excluded from analysis