Fig. 6.

A Oxidization stress and pH triggered PTX drug release profiles from PTX-loaded P₄ copolymer micromicelles at 37 °C and various pH and H₂O₂ concentrations: (a) pH 7.4, (b) pH 6.3, (c) pH 5.3, (d) pH 5.3 and 0.2% H₂O₂, and (e) pH 5.3 and 0.8% H₂O₂, and free PTX release at medium of (f) pH of 7.4 and (g) pH of 5.3 and H₂O₂ of 0.8%; and B cytotoxicity of (a) free PTX, (b) blank P₄ and (c) PTX-loaded P₄ micromicelles at pH 7.4, and (d) PTX-loaded P₄ micromicelles at pH of 5.3 and a H₂O₂ concentration of 0.8% against A549 lung cancer cell lines at 37 °C after 24 h incubation