Table 7.

Genes associated with mitochondrial function identified to be regulated by IL-10 in monocytes stimulated by N. meningitidis

Symbol	Entrez gene name	Location	Type(s)	Fold change1
				Nm vs ctr	Nm + IL-10 vs ctr	Nm + IL-10 vs Nm
ACO2	aconitase 2, mitochondrial	Cytoplasm	Enzyme	−1.66	−1.33	1.25
ATP5A1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	Cytoplasm	Transporter	−1.83	−1.34	1.37
ATP5H	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d	Cytoplasm	Enzyme	−1.50	−1.18	1.27
BCL2	B-cell CLL/lymphoma 2	Cytoplasm	Transporter	NC	NC	−1.46
CASP3	caspase 3, apoptosis-related cysteine peptidase	Cytoplasm	Peptidase	NC	1.86	1.79
COX7C	cytochrome c oxidase subunit VIIc	Cytoplasm	Enzyme	−1.66	NC	1.45
CYB5A	cytochrome b5 type A (microsomal)	Cytoplasm	Enzyme	−1.69	NC	1.48
FURIN	furin (paired basic amino acid cleaving enzyme)	Cytoplasm	Peptidase	−2.47	1.42	3.51
NCSTN	nicastrin	Plasma Membrane	Peptidase	−1.41	1.17	1.21
NDUFA6	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14 kDa	Cytoplasm	Enzyme	−2.00	−1.53	1.31
NDUFA9	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39 kDa	Cytoplasm	Enzyme	1.28	3.10	2.43
NDUFA10	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42 kDa	Cytoplasm	Transporter	−1.38	−1.14	1.22
NDUFAB1	NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8 kDa	Cytoplasm	Enzyme	−2.26	−1.56	1.45
NDUFB5	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16 kDa	Cytoplasm	Enzyme	−1.48	NC	1.37
NDUFS2	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49 kDa (NADH-coenzyme Q reductase)	Cytoplasm	Enzyme	−2.04	NC	1.92
NDUFS6	NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13 kDa (NADH-coenzyme Q reductase)	Cytoplasm	Enzyme	−1.74	−1.42	1.22
NDUFV2	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24 kDa	Cytoplasm	Enzyme	NC	−1.61	−1.44
PRDX3	peroxiredoxin 3	Cytoplasm	Enzyme	−1.63	NC	1.47
SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	Cytoplasm	Enzyme	−1.91	−1.41	1.35
TRAK1	trafficking protein, kinesin binding 1	Nucleus	Other	−1.29	NC	1.25
UCP2	uncoupling protein 2 (mitochondrial, proton carrier)	Cytoplasm	Transporter	−2.07	−1.49	1.39
UQCR10	ubiquinol-cytochrome c reductase, complex III subunit X	Cytoplasm	Enzyme	−1.75	−1.38	1.26
VPS9D1	VPS9 domain containing 1	Other	Transporter	NC	NC	1.86

¹Significantly expressed genes identified with two-way ANOVA, P < 0.05 after correction for multiple testing using the Benjamini-Hochberg method for correcting the false discovery rate [36]. NC denotes P-value >0.05