Table 1.

Animal data and laboratory findings in the study groups

	Control	Ade	Ade + S	Ade + C	Ade + SC
Number of animals	12	20	16	16	16
Body weight (g)
week 0	406 ± 8	409 ± 5	409 ± 5	409 ± 5	409 ± 5
week 12	450 ± 11	339 ± 6*	341 ± 6*	340 ± 7*	359 ± 8*
Chow intake at week 10 (g/24 h)	20.3 ± 1.0	13.9 ± 0.3*	16.5 ± 0.5*†	15.1 ± 0.7*	14.8 ± 0.8*
Systolic blood pressure (mmHg)
week 0	139 ± 1	138 ± 1	139 ± 1	138 ± 1	139 ± 1
week 9	137 ± 2	138 ± 1	130 ± 2†	138 ± 1‡	129 ± 2*†
Drinking volume (ml/24 h)	31.0 ± 1.9	87.5 ± 2.9*	88.1 ± 1.8*	83.5 ± 3.5*	81.2 ± 2.4*
Urine volume (ml/24 h)	20.0 ± 2.3	73.9 ± 2.2*	82.7 ± 2.7*‡	69.1 ± 3.8*‡	54.7 ± 2.5*†
24-h creatinine clearance (μl/min/kg)a	379 ± 23	82 ± 6*	119 ± 8*†	96 ± 11*	122 ± 13*†
Final plasma
Sodium (mmol/l)	135.1 ± 0.7	138.3 ± 0.5*	141.5 ± 0.6*†	140.1 ± 0.5*	140.7 ± 0.5*†
Potassium (mmol/l)	3.63 ± 0.09	4.34 ± 0.07*	4.22 ± 0.08*	4.19 ± 0.12*	4.05 ± 0.07*
Cholesterol (mmol/l)	1.45 ± 0.05	2.32 ± 0.10*	1.78 ± 0.09†	1.99 ± 0.10*‡	1.61 ± 0.05†
HDL (mmol/l)	0.60 ± 0.02	0.91 ± 0.04*	0.70 ± 0.02†	0.82 ± 0.04*	0.69 ± 0.02*†
Trigly (mmol/l)	1.06 ± 0.14	1.14 ± 0.10	0.86 ± 0.10	0.98 ± 0.08‡	0.68 ± 0.04†
Non-HDL (mmol/l)	0.86 ± 0.04	1.41 ± 0.07*	1.08 ± 0.08†	1.17 ± 0.07*‡	0.92 ± 0.04†
Proteins (g/l)	53.4 ± 1.0	51.9 ± 0.8	52.8 ± 1.2	51.1 ± 1.5	51.9 ± 0.9

Mean ± SEM; Ade, 0.3% adenine diet; S, sitaxentan 50 mg/kg/day; C, cinacalcet 20 mg/kg/day; ^aestimated from urine collection during week 10 and final plasma creatinine; *p < 0.05 vs. Control; †p < 0.05 vs. Ade; ‡p < 0.05 vs. Ade + SC