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. 2017 Oct 26;11:99. doi: 10.1186/s12918-017-0474-5

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Network of genes derived from GeneMANIA (based on 244 studies in humans) using the most predictive set of SNPs in this study. The connections in pink are derived from gene coexpression data, whereas the connections in green are derived from genetic interaction data from the literature. The inner circle is composed of genes on which the subset of SNPs in SNP Set-2 leading to optimal performance in both cohorts are present, whereas the genes forming the outer circle are additional genes identified by GeneMANIA. The thicknesses of the links (or edges) between the genes are proportional to the interaction strengths, whereas the node size for each gene is proportional to the rank of the gene based on its importance (or gene score) within the network. All interactions within this network are listed in Additional file 1: Table S8