Table 3.
Predictive importance values of the set of SNPs that generate optimal predictive performance in both cohorts. Nearest genes are listed for intergenic SNPs (marked with asterisk)
| SNP | Locus | Predictive importance | Predictive importance | Percent |
|---|---|---|---|---|
| (ClinSeq®;) | (FHS) | difference | ||
| rs13159307 | FBXL17 * | 28.83 | 21.64 | 24.94 |
| rs8107904 | EMR2 * | 36.95 | 21.83 | 40.92 |
| rs571797 | NRG3 | 17.68 | 6.86 | 61.20 |
| rs2390285 | MACC1 | 22.86 | 17.27 | 24.45 |
| rs342393 | NRG3 | 18.04 | 15.34 | 14.97 |
| rs13429160 | LOC101927701 | 35.68 | 16.89 | 52.66 |
| rs11674863 | LOC101927701 | 26.18 | 15.74 | 39.88 |
| rs514237 | NRG3 | 19.09 | 24.81 | 23.06 |
| rs6860493 | NNT | 20.72 | 26.39 | 21.49 |
| rs10054519 | C5orf28 | 21.17 | 25.25 | 16.16 |
| rs12521249 | PAIP1 * | 21.17 | 25.44 | 16.78 |
| rs10065689 | NNT | 20.45 | 25.55 | 19.96 |
| rs2241097 | TLR5 | 34.02 | 24.11 | 29.13 |
| rs10059993 | NNT-AS1 | 20.82 | 24.77 | 15.95 |
| rs12645809 | ANTXR2 | 22.1 | 25.33 | 12.75 |
| rs480220 | NRG3 | 19.76 | 24.01 | 17.70 |
| rs1366410 | NNT | 21.15 | 23.77 | 11.02 |
| rs11767632 | YAE1D1 * | 32.09 | 20.94 | 34.75 |
| rs7713479 | NNT-AS1 | 21.11 | 37.48 | 43.68 |
| rs243172 | FOXN3 | 34.90 | 46.17 | 24.41 |
| rs243170 | FOXN3 | 35.91 | 51.20 | 29.86 |
The normalized difference of the predictive importance values of each SNP in two cohorts (difference divided by the higher predictive importance value in the two cohorts) has a median value of 24% (interquartile range:17%-36%). In terms of predictive importance based ranking, five of the top 11 SNP predictors (with 65% of the cumulative predictive importance) are common, whereas nine of the top 14 SNP predictors (with 76% of the cumulative predictive importance) overlap between two cohorts
*Intergenic SNPs for which the nearest genes are reported