Table 4.
Enriched diseases and biological functions (in the network of genes derived from GeneMANIA) with p-values ranging between 1.0E-4 and 1.0E-2 as identified by IPA based on Fisher’s exact test
| Category | Disease or function | Genes | p-value |
|---|---|---|---|
| Connective tissue development and function | Quantity of adipose tissue | ARID5B, CYB5R4 | 3.58E-4 |
| RETN, TLR5 | |||
| Connective tissue development and function | Differentiation of adipocytes | ARID5B, EGLN1 | 8.82E-4 |
| NIPBL, RETN | |||
| Cardiovascular disease | Angiectasis of blood vessel | EGLN1 | 9.87E-4 |
| Cardiovascular system development and function | Area of capillary vessel | EGLN1 | 9.87E-4 |
| Hematological system development and function | Cell division of | AIMP1 | 9.87E-4 |
| peripheral blood lymphocytes | |||
| Cardiovascular disease, endocrine system disorders, | Susceptibility to insulin | RETN | 9.87E-4 |
| Metabolic disease | resistance-related hypertension | ||
| Cardiac necrosis, cell death and survival | Cell death of heart tissue | EGLN1 | 1.97E-3 |
| Cellular movement | Migration of connective tissue cells | AIMP1, ARID5B | 2.14E-3 |
| RETN | |||
| Carbohydrate metabolism, cellular function | Homeostasis of D-glucose | CYB5R4, RETN | 2.46E- 3 |
| and maintenance | TLR5 | ||
| Nucleic acid metabolism | Conversion of NAD+ | NNT | 2.96E- 3 |
| Cardiovascular system development and function | Tethering of endothelial cell lines | FUT3 | 2.96E-3 |
| Cellular compromise, inflammatory response | Degranulation of beta islet cells | CYB5R4 | 3.94E-3 |
| Cardiovascular system development and function | Density of blood vessel tissue | AIMP1 | 3.94E-3 |
| Endocrine system disorders, hematological disease | Onset of hyperglycemia | CYB5R4 | 3.94E-3 |
| Metabolic disease | |||
| Carbohydrate metabolism | Tolerance of D-glucose | CYB5R4 | 4.93E- 3 |
| Cardiovascular system development and function | Angiogenesis of heart | EGLN1 | 5.91E-3 |
| Cardiovascular system development and function | Density of blood vessel | AIMP1, EGLN1 | 5.96E-3 |
| Immune cell trafficking, inflammatory response | Adhesion of neutrophils | ADGRE2 (EMR2) | 7.52E-3 |
| Hematological system development and function | TLR5 | ||
| Endocrine system development and function | Insulin sensitivity of liver | RETN | 7.87E-3 |
| Hepatic system development and function | |||
| Nucleic acid metabolism | Metabolism of NADPH | CYB5R4 | 7.87E-3 |
| Connective tissue development and function | Quantity of visceral fat | RETN | 8.85E- 3 |
| Carbohydrate metabolism | Binding of chondroitin sulfate | ADGRE2 (EMR2) | 9.83E-3 |
51 additional enriched diseases and biological functions (statistically less significant) with p-values ranging between 1.0E-2 and 5.0E-2 are listed in Additional file 1: Table S7