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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Diabetes Obes Metab. 2017 Sep;19(Suppl 1):147–152. doi: 10.1111/dom.13019

Figure 1.

Figure 1

Mass cytometry defines four human beta-cells states or subtypes. Single cell suspensions were prepared from human islets and subjected to mass cytometry (CyTOF) with 24 heavy isotope-labeled antibodies. After gating for only C-peptide positive beta-cells, beta cells were next analyzed by the t-distributed stochastic neighbor embedding (t-SNE) algorithm for dimensionality reduction to visualized beta-cell subtypes. Colors indicate density of the cells, and subgroups were manually gated based on natural occurring groups. From Wang et al., 2016. Cell Metabolism (Reference 12), with permission.