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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Placenta. 2017 Jun 6;57:26–32. doi: 10.1016/j.placenta.2017.06.001

Figure 2.

Figure 2

Effects of maternal diabetes on PGC-1α/TFAM/Mitochondrial DNA abundance in placentae of male offspring. Protein extracts subjected to Western blot analysis and DNA extracts were analyzed by quantitative RT-PCR. A and B: Representative Western blots and quantitation of PGC-1α (A) and TFAM (B) in male placentae of diabetic women (DM, n=10) and non-diabetic controls (n=10). C: Fold change of mitochondrial tRNALeu(UUR) gene DNA copy number normalized to β2-microglobin (B2M); n=9 for DM, n=10 for control. D: Correlation between PGC-1α and TFAM protein levels. E: Correlation between mtDNA copy number to TFAM protein levels. Open square: control group; Solid square: DM. Bar graphs are presented as mean ± SD, * P<0.05; ** P<0.01; *** P<0.001.