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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Expert Rev Mol Diagn. 2016 Dec;16(12):1337–1351. doi: 10.1080/14737159.2016.1259069

Figure 1.

Figure 1

In normal cells with intact BRCA, PARP functions to repair DNA normally. Treatment with PARP inhibitors inhibits a cell’s ability to repair its DNA and leads to cell death. There are multiple mechanisms of PARP inhibitor resistance.