Figure 1.

Rapamycin treatment reduces, but does not normalize, the increased activity of hilar inhibitory interneuron 8–12 weeks after CCI injury. A, Representative traces showing spontaneous action potential firing from three different treatment groups: control (i.e., sham and contralateral neurons), ipsilateral to CCI injury + vehicle (CCI Ipsi), and ipsilateral to CCI injury + 3 mg/kg rapamycin (CCI + Rapa Ipsi). B, Mean spontaneous action potential firing in sham, CCI Contra, CCI Ipsi, CCI + Rapa Contra, and CCI + Rapa Ipsi groups. Error bars indicate SEM; *p < 0.05 compared to sham and contralateral hemispheres; #p < 0.05 for CCI Ipsi versus CCI + Rapa Ipsi.