Figure 2.

Rapamycin treatment reduces, but does not normalize, the increase in sEPSC frequency in hilar inhibitory interneurons 8–12 weeks after CCI injury. A, Representative traces showing sEPSCs in eGFP+ neurons from three different treatment groups: control (i.e., sham and contralateral neurons), ipsilateral to CCI injury + vehicle (CCI Ipsi), and ipsilateral to CCI injury + 3 mg/kg rapamycin (CCI + Rapa Ipsi). Expanded sections of the trace under the black line are indicated by arrows. B, Mean sEPSC frequency, amplitude, and whole-cell capacitance in sham, CCI Contra, CCI Ipsi, CCI + Rapa Contra, and CCI + Rapa Ipsi groups. Error bars indicate SEM; *p < 0.05 compared to sham and contralateral hemispheres; #p < 0.05 for CCI Ipsi versus CCI + Rapa Ipsi; †p < 0.05 compared to sham, CCI Contra, and CCI Ipsi.