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. 2017 Oct 20;11:3065–3075. doi: 10.2147/DDDT.S143942

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© 2017 Gao et al. This work is published and licensed by Dove Medical Press Limited

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Typical histopathological images of major organs of sarcoma 180 tumor-bearing mice (magnification ×400).

Notes: (A) Normal morphology of liver, (B) liver tissue of mouse receiving intraperitoneal injection of MTX solution, (C) liver tissue of mouse receiving intratumoral implantation of high doses of MTX-loaded implants, (D) normal morphology of kidney, (E) kidney tissue of mouse receiving intraperitoneal injection of MTX solution, (F) kidney tissue of mouse receiving intratumoral implantation of high doses of MTX-loaded implants.

Abbreviation: MTX, methotrexate.