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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Emerg Top Life Sci. 2017 Apr 21;1(1):75–83. doi: 10.1042/ETLS20160019

Figure 2. Variation in cdi gene clusters.

Figure 2

The cdi loci of selected bacterial strains are presented. Where available, ordered locus designations are provided below each cdiA gene. Secretion and accessory genes (cdiB, bcpO and hlyC) are depicted in yellow, and predicted immunity genes are shown in green. Genes encoding transposases, integrases and other proteins associated with mobile genetic elements are presented in light cyan. Orphan cdiA-CT/cdiI gene pairs are indicated by number (e.g. o1, o2, etc.) corresponding to their position downstream of the main cdiBAI cluster. The downward pointing carats indicate the position of sequences encoding VENN (or ELYN) peptide motifs that demarcate the variable CdiA-CT toxin region. Asterisks indicate that the orphan cdiA-CT sequence harbors mutations that are predicted to inactivate the encoded toxin domain.