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Schematic of (A) YAP and (B) TAZ regulatory domains and phosphorylation sites. Several residues described to be phosphorylated are highlighted, including S397 within human YAP-Isoform1, at which phosphorylation by Lats1/2 is known to prime YAP for SCF-βTRCP-mediated proteasomal degradation, and is now shown by Hu et al. to be dephosphorylated by FAK-CDC42-PP1A signaling cascade.
