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View full-text article in PMC

. Author manuscript; available in PMC: 2017 Oct 27.

Published in final edited form as: Virology (Hyderabad). 2017 Jul 31;1(1):104.

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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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HCMV-encoded antagonists of the NFκB signalling pathway. NFκB signalling can be induced by activation of a variety of cell surface receptors as well as HCMV binding and entry. Upstream signalling cascades culminate at the activation of the IKK complex. Several HCMV proteins and miRNAs (shown in red) block activation of the IKK complex or downstream binding of the NFκB transcription factors to their cognate sequences.