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. 2016 Nov 15;37(3):514–626. doi: 10.1002/med.21420

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© 2016 The Authors Medicinal Research Reviews Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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RCA template and hybridization efficiency. (A) Secondary structure of scrambled rolling circle amplification (RCA) template. (B) Secondary structure of a dual antisense oligonucleotide (ASO) hybridizing RCA template for Dz‐13 and OGX‐427. (C) RCA products with poly ASO‐binding sequences were hybridized with two therapeutic ASOs, Dz‐13 and OGX‐427, to produce dual ASO‐hybridizing RCA products. (D) The hybridization efficiencies of the ASOs were tested for products of scrambled RCA templates and dual ASO‐hybridizing RCA templates using fluorescently labeled ASOs. Reprinted from 365. Copyright 2015, with permission from Elsevier.