Figure 12.

Model integrating the changes in the mediators of insulin sensitivity induced by prenatal T excess in the metabolic tissues as it relates to target site–specific insulin sensitivity along with the intermediaries that participate in their regulation. (a) Observed changes in the mediators of insulin sensitivity in liver, muscle, and visceral fat. How the changes in mediators of insulin sensitivity might integrate in the development of the insulin resistant state in liver and muscle and the insulin-sensitive state of visceral fat are shown. (b) Steroidal and metabolic components involved in organizing and maintaining (through activational effects) the positive and negative mediators of insulin sensitivity.