Figure 8.

Glucose homeostasis was mildly altered after 1 week of letrozole treatment. (a–e) In vivo GSIS test; n = 8 per group. (a) Changes in blood glucose over time during GSIS. (b) FBG was increased in letrozole-treated mice; *P < 0.05 by t test. (c) Blood glucose area under the curve (AUC) was increased in letrozole-treated mice; *P < 0.05 by t test. (d) Serum insulin levels during GSIS and (e) percent relative to basal insulin demonstrated that insulin secretion in response to exogenous glucose stimulation was not statistically different between groups. Serum insulin levels were significantly increased at 10 minutes postinjection; *P < 0.05 by one-way repeated-measures analysis of variance. (f) Fasting glucagon was increased in letrozole-treated mice; *P < 0.05 by t test.