Table 4.
Cortical Geometry: Anabolic Therapies
| Group | Cortical Thickness | Marrow Area | Total Area | Endocortical Perimeter | Periosteal Perimeter | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| VEH: WT/Nmp4−/− | 0.190 ± 0.016/0.184 ± 0.007 | 0.964 ± 0.096/0.958 ± 0.026 | 1.841 ± 0.109/1.834 ± 0.092 | 3.843 ± 0.185/3.861 ± 0.121 | 5.243 ± 0.167/5.242 ± 0.175 | |||||
| PTH: WT/Nmp4−/− | 0.201 ± 0.009/0.196 ± 0.009 | 1.029 ± 0.090/0.992 ± 0.069 | 2.028 ± 0.118/2.024 ± 0.096 | 2.028 ± 0.118/3.955 ± 0.088 | 5.508 ± 0.172/5.476 ± 0.130 | |||||
| PTH+ALN: WT/Nmp4−/− | 0.200 ± 0.014/0.197 ± 0.007 | 1.046 ± 0.082/0.907 ± 0.129 | 2.074 ± 0.078/2.015 ± 0.145 | 4.104 ± 0.214/4.023 ± 0.302 | 5.633 ± 0.076/5.497 ± 0.235 | |||||
| PTH+ZOL: WT/Nmp4−/− | 0.207 ± 0.009/0.198 ± 0.011 | 1.012 ± 0.084/0.957 ± 0.092 | 2.074 ± 0.159/2.061 ± 0.126 | 4.038 ± 0.151/4.301 ± 0.477 | 5.595 ± 0.246/5.543 ± 0.220 | |||||
| PTH+RAL: WT/Nmp4−/− | 0.206 ± 0.015/0.203 ± 0.020 | 0.891 ± 0.136/0.822 ± 0.149 | 2.061 ± 0.116/2.005 ± 0.111 | 3.958 ± 0.404/3.860 ± 0.262 | 5.550 ± 0.225/5.546 ± 0.327 | |||||
| Anabolic therapy | G: P = 0.0501 | G: P = 0.0028 | G: P = 0.23 | G: P = 0.9952 | G: P = 0.28 | |||||
| T: P = 0.0003 | T: P < 0.0001 | T: P < 0.0001 | T: P = 0.0029 | T: P < 0.0001 | ||||||
| PTH+RAL | A | PTH | A | PTH+ZOL | A | PTH+ZOL | A | PTH+ZOL | A | |
| PTH+ZOL | A | PTH+ZOL | A | PTH+ALN | A | PTH+ALN | AB | PTH+ALN | A | |
| PTH | A | PTH+ALN | A | PTH+RAL | A | PTH | AB | PTH+RAL | A | |
| PTH+ALN | A | VEH | A | PTH | A | PTH+RAL | B | PTH | A | |
| VEH | B | PTH+RAL | B | VEH | B | VEH | B | VEH | B | |
| GxT: P = 0.92 | GxT: P = 0.92 | GxT: P = 0.89 | GxT: P = 0.18 | GxT: P = 0.86 | ||||||
The micro-CT analyses of the femoral cortical geometry in mice treated with the anabolic therapies. The data were analyzed using two-way analyses of variance to compare the anabolic therapies and the anticatabolic monotherapies. Statistical significance was set at P ≤ 0.05, and levels not connected by the same letter are significantly different. The data represent mean ± standard deviation, n = 7 to 12 mice per group.
Abbreviations: G, genotype; T, treatment.