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. 2017 Jul 5;158(9):2955–2969. doi: 10.1210/en.2017-00196

Figure 6.

Figure 6.

Changes in Leydig cell morphology and volume after Sertoli cell ablation. (a) Adult Leydig cell morphology in control animals and after partial ablation of Sertoli cells in the fetus (DTA mice), neonate (iDTR mice treated with DTX), and adult mice (iDTR mice treated with DTX). Leydig cell morphology was largely unchanged after fetal Sertoli cell ablation, but there was an apparent decrease in cell volume after neonatal or adult ablation of Sertoli cells. The bars in these images represent 10 µm. (b) Adult Leydig cell volume measured by the uniform isotropic random rotator method after Sertoli cell ablation in the fetus (DTA) or neonate (DTX). Data show mean ± standard error of the mean (n = 6 to 11 animals in each group). *P < 0.05 vs control. (c) Correlation between Leydig cell volume and Sertoli cell number in individual animals after adult Sertoli cell ablation (r = 0.891; P < 0.001).